in vivo Research Associate/Sr. Research Associate
Casebia Therapeutics
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Company Overview

Casebia Therapeutics is a newly formed joint venture between Bayer and CRISPR Therapeutics focused on discovering and developing new breakthrough therapeutics to cure blood disorders, eye diseases, and heart disease. Casebia has its own scientific leadership and management team enabling the Company to run as an independent and sustainable organization. CRISPR Therapeutics has contributed its proprietary CRISPR-Cas9 gene-editing technology and intellectual property, while Bayer has provided significant investment and protein engineering expertise as well as relevant disease know-how. It is the first long-term strategic partnership of its kind to make a substantial investment to bring CRISPR-Cas9 gene editing technology applications to patients. For more information, please visit www.casebia.com

Job Summary

We are seeking a Research Associate/Sr. Research Associate to join an exciting, fast-growing and well-financed new company to develop novel gene editing therapies for serious diseases. The successful candidates will be integral in discovering and developing the next generation of therapies for hematological diseases. The successful candidates will have significant experience executing and analyzing in vivo experiments in hematology, specifically the hematopoietic and immune system. Basic cell and molecular biology skills are desirable. The position requires enthusiasm, passion, attention to detail, and a desire to create important new medicines for patients.

Job Responsibilities

Plan and conduct gene-editing in vivo mouse studies in support of hematology, ophthalmology/auditory, and congenital heart failure therapeutic portfolio.
Data entry, analysis, technical report writing, and presentation of experimental results in small and large group settings.
Maintain accurate and well-organized records and documentation.
Support of ex vivo and in vitro assays for downstream molecular biology and biochemistry analysis.

Required Skills & Qualifications

Research Associate - BS in biology or related discipline and minimum of 1+ years of relevant research experience.
Senior Research Associate – BS or MS in biology or related discipline and minimum of 5+ years of relevant research experience.
Extensive experience in rodent handling, experience with immunodeficient mice a plus.
Extensive experience with cell/drug delivery procedures (IV, IP, SC, IM, Oral) and blood and tissue collection.
Previous experience executing preclinical models of gene editing or bone marrow transplantation in mice utilizing human grafts (e.g., CRISPR or humanized immune system mice) a plus.
Ability to learn and conduct new in vivo experimental skills as needed is essential.
Proficient in animal welfare and local, state, and federal guidelines for animal care and use in research.
Solid working knowledge of lab equipment and techniques within area of specialty
Excellent organizational, oral and written communication skills, and attention to detail.  
A high degree of flexibility and ability to multi-task and handle multiple projects at one time.

Experience with mammalian cell culture (particularly primary hematopoietic cells), molecular and cellular biology techniques (FACS, molecular cloning, plasmid preparation, RNA and DNA isolation, PCR and qRT-PCR, SDS-PAGE/western blot, and ELISA) is a plus.

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